View abstract. Found inside – Page 139There is one kind of soluble fiber, however, that works without the nasty side effects. Glucomannan, which comes from an Asian plant known as the konjac, ... Vasques, C. A., Rossetto, S., Halmenschlager, G., Linden, R., Heckler, E., Fernandez, M. S., and Alonso, J. L. Evaluation of the pharmacotherapeutic efficacy of Garcinia cambogia plus Amorphophallus konjac for the treatment of obesity. Glucomannan is a natural, water-soluble, dietary fiber that has been extracted from the roots of the konjac tree. These are typically rare. Learn More. Glucomannan, like other types of soluble fiber, can cause gastrointestinal side effects when you suddenly increase the amount you consume. Verywell Fit's content is for informational and educational purposes only. Vuksan V, Jenkins DJ, Spadafora P, et al. View abstract. Common side effects include flatulence, diarrhea, belching, bloating, and stomach upset.. Glucomannan (From Konjac Root) Glucomannan is a water-soluble polysaccharide that is considered a dietary fiber. Always be sure to take each dose with at least 8 ounces (250 milliliters) of water. View abstract. Am.J Gastroenterol. J Am.Coll.Nutr. Side Effects and Precautions; Have you tried taking glucomannan to lose weight? On the other hand, it did nothing to improve "good" high-density lipoprotein (HDL) cholesterol or blood pressure. I take ur drugs. Most pharmacies will be able to provide you with a cheap, generic glucomannan pill capable of providing one gram of the fiber, three times per day. [Advances in the study of glucomannan from Amorphophallus]. View abstract. View abstract. Diabetes medications are also used to lower blood sugar. View abstract. Konjac or glucomannan may have some benefits, although the research is limited and mixed. View abstract. [A clinical study of the use of a combination of glucomannan with lactulose in the constipation of pregnancy]. Since using this product (in powder form) my symptoms have returned and I now have stomach soreness also. [Evaluation of the action of glucomannan on metabolic parameters and on the sensation of satiation in overweight and obese patients]. I've tried the kojnac noodles three times now and felt super nauseous the rest of the night. Glucomannan is a water-soluble dietary fiber that is derived from konjac root (Amorphophallus konjac). View abstract. Contrary to popular belief, glucomannan has less impact on blood sugar levels than expected. This is surprising given that glucomannan passes through the intestines largely intact and can absorb up to 50 times its weight in water. View abstract. [Chronic use of glucomannan in the dietary treatment of severe obesity]. View abstract. 1995;49 Suppl 3:S190-S197. Furthermore, the numbers were too small to be statistically significant. In a relevant study, a dosage of 3 g konjac glucomannan (divided in three times 1 g)/person per . Found inside – Page 91Ohio State University scientists recently studied the effects of three popular energy ... meal with a side salad that's mixed with a vinegar-based dressing, ... Arvill A, Bodin L. Effect of short-term ingestion of konjac glucomannan on serum cholesterol in healthy men. Mild side-effects can include: 18. View abstract. Found inside – Page 221On the other side, the data on the possible effects of chokeberry juice on ... polyphenols and hardly can be attributed to the presence of glucomannan. Doi, K., Matsuura, M., Kawara, A., and Baba, S. Treatment of diabetes with glucomannan (konjac mannan). Cesa, F., Mariani, S., Fava, A., Rauseo, R., and Zanetti, H. [The use of vegetable fibers in the treatment of pregnancy diabetes and/or excessive wight gain during pregnancy]. Eight adult volunteers (21 to 54 years of age) followed the study design of 3 weeks of placebo and 1 week of adaptation in which konjac glucomannan was titrated from 1.5 to 3 g daily and was maintained at 4.5 g daily during the 3-week treatment period. I have GERD and had my symptoms under control. Therefore the study only suggests that taking glucomannan may lead to weight loss. Venter, C. S., Kruger, H. S., Vorster, H. H., Serfontein, W. J., Ubbink, J. View abstract. Glucommanan flour and powder are used in food. Planta Med 2007;73(13):1384-1388. Clin Toxicol. View abstract. View abstract. There were no adverse events reported in this study. Effect of plant sterols and glucomannan on lipids in individuals with and without type II diabetes. Glucomannan fiber (from konjac root) or placebo was given in 1-g doses (two 500 mg capsules) with 8 oz water, 1 h prior to each of three meals per d. Subjects were instructed … Yeh, S. L., Lin, M. S., and Chen, H. L. Inhibitory effects of a soluble dietary fiber from Amorphophallus konjac on cytotoxicity and DNA damage induced by fecal water in Caco-2 cells. Fiber (glucomannan) is beneficial in the treatment of childhood constipation. Depending on what your health goals are, your daily dosage may shift, but generally speaking, you should take between 1 gram and 12 grams of this powdered supplement per day. While glucomannan products tend to have a constipation relief effect, other individuals find the opposite. National Institutes of Health. Follow this link for information about safe and natural appetite suppressants. Glucommanan powder, capsules, and tablets are used as medicine. View abstract. Pill Identifier Tool Quick, Easy, Pill Identification, Drug Interaction Tool Check Potential Drug Interactions, Pharmacy Locator Tool Including 24 Hour, Pharmacies. Glucomannan success rate is only 73% which means that only 73 out of 100 users did not experience Glucomannan side effects. It may also slow the absorption of sugar and cholesterol from the gut, helping to control sugar levels in diabetes, and reducing cholesterol levels. 1990;42(6):271-274. Glucomannan generic is a dietary fiber, prescribed for constipation, type 2 diabetes, and weight loss. However, neither group was closely monitored regarding how much each member of their respective group consumed during the testing. To ensure quality and safety, opt for supplements that have been tested by an independent certifying body like the U.S. Pharmacopeia (USP), ConsumerLab, or NSF International. J Asthma 2007;44(8):675-680. Can You Really Use Tribulus for More Testosterone? 1997;61(10):1739-1742. Side Effects Associated With The Use Of Glucomannan. Glucomannan is found in high concentrations in shirataki noodles, a type of gelatinous noodle with almost no calories or carbohydrates. Pittler, M. H. and Ernst, E. Dietary supplements for body-weight reduction: a systematic review. Henry, D. A., Mitchell, A. S., Aylward, J., Fung, M. T., McEwen, J., and Rohan, A. Glucomannan and risk of oesophageal obstruction. (Tokyo) 1998;44(3):423-436. Hua Xi.Yi.Ke.Da.Xue.Xue.Bao. Found inside – Page 40Often combined with caffeine , which can increase risk for adverse side effects . Not proven safe or effective for weight loss . Glucomannan Supplements ... This ensures that your ability to absorb abnormally large amounts of liquid is ensured. Short-term medicinal use consumption is also safe, as is adult consumption over a period of 16 weeks or 4 months. Scalfi, L., Coltorti, A., D'Arrigo, E., Carandente, V., Mazzacano, C., Di, Palo M., and Contaldo, F. Effect of dietary fibre on postprandial thermogenesis. View abstract. J Pediatr 2000;136:41-5. Padiatr Padol 1993;28:133-6. Glucomannan is extracted from two rare species of Konjac, a plant found in Southeast Asia. Please see a health care specialist if you have concerns about taking this drug. The treatment group received 1 gram of glucomannan 3 times a day for 8 weeks while the control group took a placebo throughout the testing period. Currently, only a few small studies suggest that taking glucomannan may result in significant weight loss for some dieters. In fact, on The Dr. Oz Show, Dr. Oz does tell viewers to be sure to dissolve the glucomannan in a shake or other drink before consuming. Unfortunately, there are quite a few glucomannan and konjac root side effects, some of which may be serious, especially for people who have specific conditions that are pre-existing. Diabetes: What Raises and Lowers Your Blood Sugar Level? We're told that to aid weight loss; this ingredient expands to feel the stomach. View abstract. Glucomannan is used for constipation, diabetes . Found inside – Page 237Tubers of the Amorphophallus konjac plant typically are harvested to yield glucomannan (also called konjac mannan). After reports of side effects, ... 2008;27(1):102-108. Side Effects & Precautions. Visit the FDA MedWatch website or call 1-800-FDA-1088. However, if the noodles are eaten after being saturated with water and the sauce may reduce the side-effects. Studies have shown that glucomannan has a positive effect on the digestive tract. The following doses have been studied in scientific research: You are encouraged to report negative side effects of prescription drugs to the FDA. Monitor blood sugar closely if you have diabetes and use glucomannan. More recent studies have safely tested glucomannan at the same dose offered by BOOMBAD over 60-days. In spite of the lack of more thorough studies, what is accepted is the fact that taking glucomannan does lead to feelings of fullness and therefore may suppress appetite in some people. Take oral drugs 1 hour before glucomannan or 4 hours . Lipozene side effects can include abdominal discomfort, constipation and diarrhea. View abstract. 1994;25(3):341-344. Experiences with three different fiber supplements in weight reduction. It may also slow the absorption of sugar and cholesterol from the gu.Common side effects include flatulence, diarrhea, belching, bloating, and stomach upset. More serious complaints of taking glucomannan can be traced to individuals sensitive to glucomannan that experienced allergic reactions such as a rash, hives, itching, swelling of the mouth or throat, wheezing, or difficulty breathing. Glucomannan has been recognized as safe by the FDA since 1994. Eur.J Clin Nutr. Glucomannan is considered harmless when taken as food. May Block Esophagus. The 7 Best Prebiotic Supplements of 2021, According to a Dietitian, New Study Sheds Light on Mental Health of Elite Athletes, Effect of glucomannan on plasma lipid and glucose concentrations, body weight, and blood pressure: Systematic review and meta-analysis, Dietary Reference Intakes (DRIs): Recommended Dietary Allowances and Adequate Intakes, Total Water and Macronutrients, The effect of glucomannan on pregnancy constipation, Safety and Efficacy of Glucomannan for Weight Loss in Overweight and Moderately Obese Adults, Glucomannan and obesity: A critical review, Glucomannan minimizes the postprandial insulin surge: a potential adjuvant for hepatothermic therapy. Mitsuoka, T. [The effect of nutrition on intestinal flora]. Due to its swelling properties, glucomannan is often used as a food additive as a thickener. Like most dietary supplement ingredients, the most commonly reported side effects of taking a powdered drink blend that includes glucomannan are nausea and general digestive upset. Stop using glucomannan at least 2 weeks before a scheduled surgery. Am.J.Clin Nutr. A search of literature related to the safety of taking glucomannan reveals reports that taking a tablet form rather than the capsule form of glucomannan can result in the tablet sticking to the tissues of the esophagus and hindering swallowing. Learn its indications, dosage, how to take, when to take, when not to take, side effects . View abstract. Glucomannan is considered harmless when taken as food. Glucomannan is a very beneficial soluble dietary fiber taken out from the roots of Konjac plant. With no harsh chemicals, strange drugs, or additives, glucomannan powder (flour) and capsules are considered "likely safe" to use as an appetite suppressant. The quality of reviewed studies was moderate to poor. Return to the Herb List. View abstract. Side effects. Glucomannan is a soluble fiber, the kind that absorbs water and turns into a gel during digestion. Zeng, X. Y. View abstract. Side effects Shirataki noodles are generally well-tolerated. Doi K, Matsuura M, Kawara A, Baba S. Treatment of diabetes with glucomannan (konjac mannan). 2008;99(6):1380-1387. Thank you, {{form.email}}, for signing up. A., Wright, J., and Marks, V. The effect of soluble- and insoluble-fibre supplementation on post-prandial glucose tolerance, insulin and gastric inhibitory polypeptide secretion in healthy subjects. Normally, the consumption of glucomannan is considered absolutely safe. Diarrhoea. Int.J Obes. Side Effects. In a WebMD “User Reviews and Ratings” of glucomannan, one reviewer stated that her daughter took a glucomannan pill for two months and developed internal bleeding that had to be treated at an emergency room. vitamins, herbs, dietary supplements a-z listglucomannan. Marsicano, L. J., Berrizbeitia, M. L., and Mondelo, A. Influence of dietary fiber (konjac mannan) on absorption of vitamin B12 and vitamin E (abstract). Other studies have shown that taking glucomannan supplements before a meal may provide a transient drop in blood glucose but had no demonstrable effect on insulin or HbA1c levels. Glucomannan is a sugar made from the root of the konjac plant (Amorphophallus konjac). Zhang, M. Y., Huang, C. Y., Wang, X., Hong, J. R., and Peng, S. S. The effect of foods containing refined Konjac meal on human lipid metabolism. In a systematic review in 2008, glucomannan was found to lower so-called bad cholesterol. Find helpful customer reviews and review ratings for NOW Supplements, Glucomannan (Amorphophallus konjac)575 mg, 180 Count Capsules at Amazon.com. It can potentially reduce the availability of oral medications and supplements to the body. Marzio, L., Del, Bianco R., Donne, M. D., Pieramico, O., and Cuccurullo, F. Mouth-to-cecum transit time in patients affected by chronic constipation: effect of glucomannan. Preliminary studies have shown that Glucomannan is a safe remedy to use since it lacks chemicals and additives. The problem becomes compounded when water is taken to wash the stuck tablet and instead causes the tablet to swell further and increase blockage. Henry DA, Mitchell AS, Aylward J, et al. Some women have reported bloating after taking konjac root because of how it expands. Found inside – Page 176Side effects secondary to caffeine may be expected. ... Amorphophallus konjac, the konjac root, contains glucomannan, a dietary fiber comprised of a ... Clinical data. 2001;2(3):824-826. It is located in more than a few general research centers, one of which lasted three months. 1995;49(1):7-14. While diarrhea can be a side effect, this doesn't mean glucomannan is effective for treating constipation. Glucomannan is also believed to promote weight loss, slow the aging process, and even fight certain forms of cancer. However, solid tablets containing glucomannan are POSSIBLY UNSAFE for adults and LIKELY UNSAFE for children. Get nutrition tips and advice to make healthy eating easier. J Med Assoc.Thai. First and foremost, you need to be vigilant about drinking enough water. Shirataki are often used as a pasta substitute in low-carb diets and take well to stir-frying and soups. Metabolism 2007;56(8):1149-1158. Glucommanan powder, capsules, and tablets are used as medicine. Is It Necessary to Give Your Child a Fiber Supplement? Birketvedt, G. S., Shimshi, M., Erling, T., and Florholmen, J. A., Hatfield, D. L., Ho, J. Y., Fragala, M. S., Maresh, C. M., and Volek, J. S. Effect of adding exercise to a diet containing glucomannan. If you find this page useful share it with others. In human studies, gastrointestinal discomfort (i.e. Found inside – Page 463Side-effects: often well tolerated, especially if taken with meals. ... Glucomannan Glucomannan is high in fibre, derived from Amorphophallus konjac. Minerva Med 1992;83:135-9. Diabetes Care 1999;22:913-9. Archive | Privacy Policy | Disclaimer | About Us, Editorial Review Process | Advertise | Contact | Contributors | Republish EmaxHealth Stories. Found inside – Page 129Possible Side Effects and Interactions Glucomannan may cause obstruction of the esophagus and / or gastrointestinal tract . If it's taken in combination ... [Article in Italian] Clin Ter 1995;146:269-74. Childhood obesity treatment: double blinded trial on dietary fibres (glucomannan) versus placebo. Glucomannan is made from the root of the konjac plant (Amorphophallus konjac). Read honest and unbiased product reviews from our users. Keithley, J. and Swanson, B. Glucomannan and obesity: a critical review. Zhongguo Zhong.Yao Za Zhi. View abstract. Glucomannan has also been shown to lower blood cholesterol levels and promote weight loss. In a study involving 160 overweight subjects, glucomannan use helped increase weight loss by about 50 - 80% more than the placebo. For some, the glucomannan in shirataki noodles may cause mild digestive issues, such as loose stools, bloating and flatulence ( 1 ). The same study found glucomannan improved bowel function by 30%. In the past, manufacturers like Vitacost, PediaLean, Herbal Worldwide Holdings, BioTrim, and Obesity Research Institute have been charged by U.S. Food and Drug Administration (FDA) or Federal Trade Commission (FTC) with making false claims about glucomannan supplements. For children, doses should not exceed 100 milligrams per kilogram per day (mg/kg/day). However, because of its ability to absorb water and swell many times the normal size of its dried state, glucomannan is more popularly known as a potential weight loss supplement that acts as an appetite suppressant. Minerva Ginecol. Glucomannan powders, capsules, and tablets are widely available online and sold in many natural food stores and shops specializing in dietary supplements. While this is one of the main ways it helps weight loss, it can be uncomfortable. Yes, you read that right. 1999;24(1):6-8. Nutr.Metab Cardiovasc.Dis. Increasing your fiber intake may come with initial digestive discomfort, such as bloating, gas and diarrhea. Side Effects of Lipozene 1. Effect of glucomannan on obese patients: a clinical study. To avoid this, push the supplement down with enough water when you take it. In a relevant study, a dosage of 3 g konjac glucomannan (divided in three times 1 g)/person per . Found inside – Page 236... while being less likely to cause unwanted side effects. ... Glucomannan is a water-soluble, fermentable fiber derived from an Asian plant called the ... One suggestion is that tablet forms should be totally avoided because of their potential to swell before reaching the stomach and that users should use only the capsule form to prevent the chance of early esophageal swelling. The comparative analysis of the results obtained in both groups showed that the diet + glucomannan group had a more significant weight loss in relation to the fatty mass alone, an overall improvement in lipid status and carbohydrate tolerance, and a greater adherence to the diet in the absence of any relevant side effects. Glucomannan is not recommended during pregnancy and lactation, and it is not advisable in case of hypersensitivity to the active ingredient, in case of pathologies of the esophagus and intestinal obstruction. 2005;11(6):30‐34. Glucommanan powder, capsules, and tablets are used as medicine. Found inside... diets constipation is one of the most commonly reported adverse effects. ... soluble fibre par excellence is konjac fibre, which is high in glucomannan. View abstract. Koroskenyi, B. and McCarthy, S. P. Synthesis of acetylated konjac glucomannan and effect of degree of acetylation on water absorbency. View abstract. Last night I was wheezing. Morgan, L. M., Tredger, J. Keithley J, Swanson B. Glucomannan and obesity: A critical review. Like most high-fiber products, however, it may cause digestive problems such as: . I won't be eating these again. Forty-sixth report of the Joint FAO/WHO Expert Committee on Food Additives. 2008;27(1):22-30. If you want to go straight to the source, you may be able to find konjac root in larger Asian grocery stores. Soluble fiber of any sort can help maintain or improve digestion. View abstract. Ital J Gastroenterol 1991;23:421-5. Gut 1988;29(7):930-934. These can include bloating, stomach pains, loose stools, flatulence and diarrhea. Villaverde, A. F., Benlloch, S., Berenguer, M., Miguel, Rayon J., Pina, R., and Berenguer, J. View abstract. Taking glucomannan along with medications taken by mouth can decrease how much medicine your body absorbs, and decrease the effectiveness of your medication. Glucomannan side effects. 10-15-1986;119(1):17-23. Appl.Microbiol.Biotechnol. It is also known by other names such as konjak, konjaku, and konnyaku potato. 2002;59(2-3):182-189. Found inside – Page 277Glucomannan has greatest viscosity, which is enhanced when combined with alginate ... but have side effects: flatulence, diarrhea, and abdominal discomfort. Lancet 5-5-1979;1(8123):987-988. Glucomannan has also been found to cause bloating, flatulence, and soft stools or diarrhea. In foods, glucomannan is used as a thickener or gelling . A., Crandall, M. S., and Floyd, R. Respiratory sensitization of a food manufacturing worker to konjac glucomannan. Found inside – Page 190Major side effects of orlistat are fatty stool and gastrointestinal upset; fiber supplements (e.g., glucomannan) can be used to help control side effects. Found inside – Page 116Side effects such as intolerance and tastelessness of the fiber product may ... healthy constipated children showed the beneficial effects of glucomannan (a ... Onishi, N., Kawamoto, S., Suzuki, H., Hide, M., and Ono, K. Development of autoantibody responses in NC/Nga mice: its prevention by pulverized konjac glucomannan feeding. Side Effects of Glucomannan Dietary Supplement. Bettina - Do you have a doctor? Glucomannan supplements are generally considered safe if taken as prescribed but are intended only for short-term use only. Flatulence. J Am Coll Nutr 2003;22:36-42. Constipation. Comment below! Sood, N., Baker, W. L., and Coleman, C. I. Glucomannan might work in the stomach and intestines by absorbing water to form a bulky fiber which treats constipation. View abstract. Prolonged use of Glucomannan can sometimes cause minor side effects. J Am.Coll.Nutr. Azezli, A. D., Bayraktaroglu, T., and Orhan, Y. Certain people, like those with irritable bowel syndrome, may need to avoid FODMAP-rich foods. Does Raspberry Ketone Promote Weight Loss? Here is a look at some of the key findings: Glucomannan may help keep cholesterol levels in check, suggests a 2008 review of studies published in the American Journal of Clinical Nutrition. Found inside – Page 414... can have serious side effects . glucomannan ( glue - CO - MAN - an ) a preparation derived from a vegetable ( konjac tuber ) used in Japanese cooking . View abstract. Found inside – Page 214No side effects were observed in those who took glucomannan . In the interests of fair reporting , it must be stated that glucomannan escorts out some of ... Vuksan V, Sievenpiper JL, Owen R, et al. When you're considering a diet supplement for weight loss, you also need to think about the possible side effects. J Am.Coll.Nutr. When used medicinally, minor side effects can include diarrhea, flatulence and bloating. If it expands before reaching the stomach, it may block the esophagus. Side effects. Arch.Dermatol.Res 2008;300(2):95-99. J Am.Coll.Nutr. Fanelli, V., Angelico, F., Stefanutti, C., Calvieri, A., and Fazio, S. [Effects of the integration of a habitual diet with glucomannan fiber in hypercholesterolemia. Signorelli, P., Croce, P., and Dede, A. View abstract. Salas-Salvado, J., Farres, X., Luque, X., Narejos, S., Borrell, M., Basora, J., Anguera, A., Torres, F., Bullo, M., and Balanza, R. Effect of two doses of a mixture of soluble fibres on body weight and metabolic variables in overweight or obese patients: a randomised trial. Adah Chung is a fact checker, writer, researcher, and occupational therapist. Pediatr Med Chir 1992;14:195-8. Found inside – Page 324... of nine clinical studies employing glucomannan concluded that this treatment did not produce significant weight loss, and that detrimental side effects ... Depending on the aims of treatment, dosages of up to 9 grams (9,000 milligrams) per day, divided into three to four doses, are considered safe. Though Glucomannan is generally considered safe, there are some potential short term digestive side effects like bloating and discomfort. Glucomannan is a reasonable option, particularly if you have chronic constipation. Konjac supplement alleviated hypercholesterolemia and hyperglycemia in type 2 diabetic subjects--a randomized double-blind trial. While it would fair to assume that this would slow the absorption of sugar (glucose) in the digestive tract, most research has shown that this doesn't occur. Acta Paediatr.Scand. Glucomannan powder or flour is LIKELY SAFE when consumed as food. Hopman, W. P., Houben, P. G., Speth, P. A., and Lamers, C. B. Glucomannan prevents postprandial hypoglycaemia in patients with previous gastric surgery. 4 Because glucomannan can absorb 50 times its weight in water, it is important that you take it with no less than . View abstract. Glucomannan has recently been televised as a safe and effective weight loss supplement that acts as a natural appetite suppressant. According to the 2013 study from Rush University, an eight-week course of glucomannan actually led to a slight increase in fasting blood glucose compared to placebo. Lancet 1979;1:987-8. Side effects of glucomannan. View abstract. Effect of dietary fiber, glucomannan, on absorption of sulfonylurea in man. Other than these side effects that users are wary about are the effects of glucomannan in the stomach. What up with that. Glucomannan Plus helps with weight loss during appetite suppression. Potential Glucomannan Side Effects. You don't need to pay for an expensive product like this to take advantage of its appetite-suppressing effects. They may also reduce the absorption of certain medications. A clinical study in familial and sporadic hyperlipoproteinemia with lipo-proteic phenotype IIa and IIb]. Horm Metab Res 1983;15:1-3. Long used in traditional Chinese medicine, glucomannan is now sold as a dietary supplement and weight loss aid. Tapola, N. S., Lyyra, M. L., Kolehmainen, R. M., Sarkkinen, E. S., and Schauss, A. G. Safety aspects and cholesterol-lowering efficacy of chitosan tablets. Is this coincidence or likely to be related ? Br.Med J (Clin Res Ed) 3-1-1986;292(6520):591-592. Glucomannan is a substance extracted from the root of the konjac plant (Amorphophallus konjac) native to Asia. Found inside – Page 441Side effects of glucomannan were usually minor . Diarrhea occurred in a small percentage of individuals given these products . Use of glucomannan has all ... However, if glucomannan undergoes expansion before it reaches your stomach, it may cause choking within your throat or oesophagus. Found inside... of glucose and mannose residues (glucomannan) and occasional side chains of α-1,6-linked galactose ... are systematic toxicity and adverse effects exerted. A study in 2008 found glucomannan may prevent constipation. View abstract. Glucomannan fiber (from konjac root) or placebo was given in 1-g doses (two 500 mg capsules) with 8 oz water, 1 h prior to each of three meals per d. Subjects were instructed … Cairella M, Marchini GAD. Found inside – Page 75In high doses, glucomannan may lead to diarrhea, bloating, and flatulence, but cutting back the dose relieves these unpleasant side effects. Glucomannan side effects. Altern.Ther.Health Med 2005;11(6):30-34. Chen HL, Sheu WH, Tai TS, et al. doi:10.4103/jfmpc.jfmpc_168_18, Keithley J, Swanson B, Mikolaitis S. Safety and Efficacy of Glucomannan for Weight Loss in Overweight and Moderately Obese Adults. Studies have shown that glucomannan has a positive effect on the digestive tract. Found inside – Page 233Major side effects of orlistat are fatty stool and gastrointestinal upset; fiber supplements (e.g., glucomannan) can be used to help control side effects. Apparently, because of glucomannan’s ability to swell considerably, the form of glucomannan taken may make a difference. However, what many do not know is that there have been reports of side effects that became medical emergencies requiring surgery for some users of glucomannan that involve blockages of the esophagus, blockages of the intestines and/or intestinal damage to the point of potential rupture. An eight-week double-blind trial was conducted to test purified glucomannan fiber as a food supplement in 20 obese subjects. Generally, glucomannan is well-tolerated.